| Date | Local Time | Stg | Home | Score | Away | Venue | TV/Att |
|
|---|
| 31/8/12 | 20:05 |
| Benetton Treviso | 12 - 6 | Ospreys | Stadio di Monigo | 3,500 |
|
| 8/9/12 | 18:30 |
| Ospreys | 13 - 16 | Ulster Rugby | Liberty Stadium | 8,566 | Video |
| 14/9/12 | 19:05 |
| Ospreys | 10 - 28 | Glasgow Warriors | Liberty Stadium | 7,159 | Video |
| 21/9/12 | 19:05 |
| Scarlets | 16 - 23 | Ospreys | Parc y Scarlets | 14,111 | Video |
| 29/9/12 | 18:30 |
| Ospreys | 30 - 15 | Munster Rugby | Liberty Stadium | 8,652 | Video |
| 5/10/12 | 19:05 |
| Zebre | 16 - 34 | Ospreys | Stadio XXV Aprile | 2,500 |
|
| 12/10/12 | 20:00 | P2 | Ospreys | 38 - 17 | Benetton Treviso | Liberty Stadium | 8,746 |
|
| 21/10/12 | 15:00 | P2 | Leicester Tigers | 39 - 22 | Ospreys | Welford Road | 20,224 |
|
| 27/10/12 | 14:30 |
| Ospreys | 26 - 9 | Connacht Rugby | Liberty Stadium | 8,231 | Video |
| 4/11/12 | 16:00 |
| Ospreys | 19 - 10 | Leinster Rugby | Liberty Stadium | 9,246 | Video |
| 9/11/12 | 19:45 | P1,P4 | Ospreys | 33 - 27 | Gloucester Rugby | Liberty Stadium | 5,738 |
|
| 17/11/12 | 17:00 | P1,P4 | Exeter Chiefs | 23 - 13 | Ospreys | Sandy Park | 7,829 |
|
| 23/11/12 | 19:05 |
| Edinburgh Rugby | 23 - 13 | Ospreys | Murrayfield | 3,128 | Video |
| 30/11/12 | 19:05 |
| Ospreys | 33 - 12 | Cardiff Blues | Liberty Stadium | 8,169 | Video |
| 8/12/12 | 14:35 | P2 | Toulouse | 30 - 14 | Ospreys | Stade Ernest Wallon | 17,865 |
|
| 15/12/12 | 13:35 | P2 | Ospreys | 17 - 6 | Toulouse | Liberty Stadium | 10,110 |
|
| 26/12/12 | 17:30 |
| Ospreys | 32 - 3 | Scarlets | Liberty Stadium | 19,443 |
|
| 31/12/12 | 16:15 |
| Newport Gwent Dragons | 3 - 14 | Ospreys | Rodney Parade | 7,018 |
|
| 4/1/13 | 19:05 |
| Ospreys | 16 - 15 | Zebre | Liberty Stadium | 7,891 |
|
| 13/1/13 | 15:00 | P2 | Ospreys | 15 - 15 | Leicester Tigers | Liberty Stadium | 13,126 |
|
| 20/1/13 | 16:00 | P2 | Benetton Treviso | 17 - 14 | Ospreys | Stadio di Monigo | 2,300 |
|
| 26/1/13 | 18:30 | P1,P4 | Newport Gwent Dragons | 18 - 14 | Ospreys | Rodney Parade | 4,607 |
|
| 3/2/13 | 17:00 | P1,P4 | Ospreys | 12 - 16 | Harlequins | Brewery Field | 2,849 |
|
| 8/2/13 | 19:05 |
| Ulster Rugby | 12 - 16 | Ospreys | Ravenhill | 10,886 | Video |
| 15/2/13 | 19:45 |
| Connacht Rugby | 22 - 10 | Ospreys | Sportsground | 4,680 |
|
| 22/2/13 | 20:00 |
| Ospreys | 24 - 7 | Edinburgh Rugby | Liberty Stadium | 5,580 |
|
| 2/3/13 | 18:30 |
| Munster Rugby | 13 - 13 | Ospreys | Thomond Park Stadium | 17,748 |
|
| 22/3/13 | 19:05 |
| Ospreys | 52 - 19 | Newport Gwent Dragons | Liberty Stadium | 9,935 |
|
| 30/3/13 | 17:15 |
| Cardiff Blues | 16 - 23 | Ospreys | Millennium Stadium | 36,174 |
|
| 13/4/13 | 18:30 |
| Ospreys | 28 - 3 | Benetton Treviso | Liberty Stadium | 9,138 |
|
| 19/4/13 | 19:35 |
| Glasgow Warriors | 35 - 17 | Ospreys | Scotstoun | 6,642 |
|
| 3/5/13 | 19:45 |
| Leinster Rugby | 37 - 19 | Ospreys | Royal Dublin Society | 17,583 |
|
|
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