But the Irishman has told his players that the first priority is to get in front before they look at a ten-point win.
He said: "You can feel and feed off the passion for this derby coming through all the players from whom we require a much more cohesive performance as we aim to first establish and protect a lead, and second to target the ten-point cushion needed to secure the 1872 Cup.
"Derbies are special occasions and all of our supporters, players and management are very much on song in terms of believing that it's about time we won this cup.
"It will be another ferocious contest and the support of our home fans will be vital to our efforts, as we go all out from start to finish.
"The fans will play a huge part on Saturday. With 140 years of history, there's a lot at stake and we need their vocal support to get across the line."
Bradley has made six changes to the side which lost as Scotstoun with Dougie Fife replacing the injured Lee Jones in the only change in the backline.
Up front Allan Jacobsen, Andy Titterrell and Geoff Cross all come into the front row, with Sean Cox and Netani Talei also boosting the pack.
Despite a nine-point win Gregor Townsend has also rung the changes, with five new faces in the Warriors starting line-up.
Stuart Hogg and Nikola Matawalu have been brought into the backline in place of Peter Murchie and Henry Pyrgos at full-back and scrum-half respectively.
And in the pack Josh Strauss, Tom Ryder and Dougie Hall all come in, and forwards coach Shade Munro has warned his players they will have to be prepared to face a huge physical battle in the Scottish capital.
He said: "We saw how physical the battle was last week and we need to be ready for Edinburgh to bring an even greater level of physicality.
"They have a very good and experienced pack and they will want to get on the front foot. They have a huge amount of talent across the back line and if they get good ball, they can hurt us.
"Last week our defence was very good for long spells of the game and we competed very well at the breakdown but we saw, particularly at the start of the second half the threat they pose."
At Murrayfield, 4.05pm.
Referee: Neil Paterson (SRU, 41st competition game)
Assistant Referees: Andy Macpherson, Adrian Graves (both SRU)
Citing Commissioner: Douglas Hunter
TMO: Jim Yuille (SRU)
Live on BBC ALBA