The new franchise have just six league points in the RaboDirect PRO12 this season - five losing bonus points and one try bonus gained against table topping Ulster in Parma in the rearranged round four match.
Glasgow Warriors have won their last three PRO12 fixtures and have been victorious in their last half a dozen games against Italian opponents since losing 13-15 to Treviso at Firhill on 23 September 2011. The Warriors' only reversal in Italy since 1998 remains the 16-19 defeat in Treviso on 16 April 2011.
Glasgow won the round five encounter with Zebre, 22-19, at Scotstoun.
At Stadio XXV Aprile , 3.05pm local time (2.05pm UK & Ireland)
Referee: Andrew McMenemy (SRU, 19th competition game)
Assistant Referees: Matteo Liperini, Stefano Marrama
Citing Commissioner: Maurizio Vancini (FIR)
TMO: Mauro Dordolo (FIR)
Live on Sportitalia and BBC ALBA
1st Floor Simmonscourt House
Ballsbridge, Dublin 4, Ireland